Published February 24, 2026 | Version v1
Directed Acyclic Graph Open

Night-shift and Metabolomics

Contributors

  • Antonio d'Errico1 ORCID icon
  • 1 Utrecht University

Visualisation

Description

The developed DAG was used in the EPHOR-NIGHT project (European Project for Health and Occupational Research Night Shift Cohort) to study night-shift work association with workers' metabolomics.

Code

CSV JSON DAGitty 
source,target,edge_type
marital status,metabolic profile,directed
marital status,night shift,directed
marital status,physical activity,directed
marital status,BMI,directed
marital status,alcohol,directed
marital status,smoking,directed
night shift,metabolic profile,directed
night shift,physical activity,directed
night shift,BMI,directed
night shift,alcohol,directed
night shift,sleep,directed
night shift,smoking,directed
physical activity,metabolic profile,directed
BMI,metabolic profile,directed
BMI,physical activity,directed
age,marital status,directed
age,metabolic profile,directed
age,night shift,directed
age,physical activity,directed
age,BMI,directed
age,alcohol,directed
age,chronotype,directed
age,education,directed
age,smoking,directed
alcohol,metabolic profile,directed
alcohol,BMI,directed
alcohol,sleep,directed
alcohol,smoking,directed
center,marital status,directed
center,metabolic profile,directed
center,physical activity,directed
center,BMI,directed
center,alcohol,directed
center,education,directed
center,origin,directed
center,smoking,directed
chronotype,metabolic profile,directed
chronotype,night shift,directed
chronotype,physical activity,directed
chronotype,BMI,directed
chronotype,alcohol,directed
education,marital status,directed
education,metabolic profile,directed
education,night shift,directed
education,physical activity,directed
education,BMI,directed
education,alcohol,directed
education,smoking,directed
origin,marital status,directed
origin,metabolic profile,directed
origin,night shift,directed
origin,physical activity,directed
origin,BMI,directed
origin,alcohol,directed
origin,education,directed
origin,smoking,directed
sex,metabolic profile,directed
sex,night shift,directed
sex,physical activity,directed
sex,BMI,directed
sex,alcohol,directed
sex,education,directed
sex,smoking,directed
sleep,metabolic profile,directed
smoking,metabolic profile,directed
smoking,physical activity,directed
smoking,BMI,directed

This JSON follows Open Causal Graph Data Standard.

{
 "nodes": [
  {
   "name": "marital status",
   "pos": [
    0.2,
    0.335
   ],
   "type": "adjusted"
  },
  {
   "name": "metabolic profile",
   "pos": [
    0.818,
    0.839
   ],
   "type": "outcome"
  },
  {
   "name": "night shift",
   "pos": [
    0.384,
    0.835
   ],
   "type": "exposure"
  },
  {
   "name": "physical activity",
   "pos": [
    0.614,
    0.593
   ],
   "type": null
  },
  {
   "name": "BMI",
   "pos": [
    0.611,
    0.478
   ],
   "type": null
  },
  {
   "name": "age",
   "pos": [
    0.057,
    0.095
   ],
   "type": "adjusted"
  },
  {
   "name": "alcohol",
   "pos": [
    0.56,
    0.143
   ],
   "type": null
  },
  {
   "name": "center",
   "pos": [
    0.057,
    0.498
   ],
   "type": "adjusted"
  },
  {
   "name": "chronotype",
   "pos": [
    0.195,
    0.607
   ],
   "type": "adjusted"
  },
  {
   "name": "education",
   "pos": [
    0.204,
    0.161
   ],
   "type": "adjusted"
  },
  {
   "name": "origin",
   "pos": [
    0.056,
    0.207
   ],
   "type": "adjusted"
  },
  {
   "name": "sex",
   "pos": [
    0.055,
    0.335
   ],
   "type": "adjusted"
  },
  {
   "name": "sleep",
   "pos": [
    0.61,
    0.739
   ],
   "type": null
  },
  {
   "name": "smoking",
   "pos": [
    0.618,
    0.33
   ],
   "type": null
  }
 ],
 "edges": [
  {
   "source": "marital status",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "marital status",
   "target": "night shift",
   "type": "directed"
  },
  {
   "source": "marital status",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "marital status",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "marital status",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "marital status",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "night shift",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "night shift",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "night shift",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "night shift",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "night shift",
   "target": "sleep",
   "type": "directed"
  },
  {
   "source": "night shift",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "physical activity",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "BMI",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "BMI",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "marital status",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "night shift",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "chronotype",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "education",
   "type": "directed"
  },
  {
   "source": "age",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "alcohol",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "alcohol",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "alcohol",
   "target": "sleep",
   "type": "directed"
  },
  {
   "source": "alcohol",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "marital status",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "education",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "origin",
   "type": "directed"
  },
  {
   "source": "center",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "chronotype",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "chronotype",
   "target": "night shift",
   "type": "directed"
  },
  {
   "source": "chronotype",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "chronotype",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "chronotype",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "education",
   "target": "marital status",
   "type": "directed"
  },
  {
   "source": "education",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "education",
   "target": "night shift",
   "type": "directed"
  },
  {
   "source": "education",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "education",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "education",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "education",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "marital status",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "night shift",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "education",
   "type": "directed"
  },
  {
   "source": "origin",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "sex",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "sex",
   "target": "night shift",
   "type": "directed"
  },
  {
   "source": "sex",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "sex",
   "target": "BMI",
   "type": "directed"
  },
  {
   "source": "sex",
   "target": "alcohol",
   "type": "directed"
  },
  {
   "source": "sex",
   "target": "education",
   "type": "directed"
  },
  {
   "source": "sex",
   "target": "smoking",
   "type": "directed"
  },
  {
   "source": "sleep",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "smoking",
   "target": "metabolic profile",
   "type": "directed"
  },
  {
   "source": "smoking",
   "target": "physical activity",
   "type": "directed"
  },
  {
   "source": "smoking",
   "target": "BMI",
   "type": "directed"
  }
 ]
}
dag {
bb="0,0,1,1"
"marital status" [adjusted,pos="0.200,0.335"]
"metabolic profile" [outcome,pos="0.818,0.839"]
"night shift" [exposure,pos="0.384,0.835"]
"physical activity" [pos="0.614,0.593"]
BMI [pos="0.611,0.478"]
age [adjusted,pos="0.057,0.095"]
alcohol [pos="0.560,0.143"]
center [adjusted,pos="0.057,0.498"]
chronotype [adjusted,pos="0.195,0.607"]
education [adjusted,pos="0.204,0.161"]
origin [adjusted,pos="0.056,0.207"]
sex [adjusted,pos="0.055,0.335"]
sleep [pos="0.610,0.739"]
smoking [pos="0.618,0.330"]
"marital status" -> "metabolic profile"
"marital status" -> "night shift"
"marital status" -> "physical activity"
"marital status" -> BMI
"marital status" -> alcohol
"marital status" -> smoking
"night shift" -> "metabolic profile"
"night shift" -> "physical activity"
"night shift" -> BMI
"night shift" -> alcohol
"night shift" -> sleep
"night shift" -> smoking
"physical activity" -> "metabolic profile"
BMI -> "metabolic profile"
BMI -> "physical activity"
age -> "marital status"
age -> "metabolic profile"
age -> "night shift"
age -> "physical activity"
age -> BMI
age -> alcohol
age -> chronotype
age -> education
age -> smoking
alcohol -> "metabolic profile"
alcohol -> BMI
alcohol -> sleep
alcohol -> smoking
center -> "marital status"
center -> "metabolic profile"
center -> "physical activity"
center -> BMI
center -> alcohol
center -> education
center -> origin
center -> smoking
chronotype -> "metabolic profile"
chronotype -> "night shift"
chronotype -> "physical activity"
chronotype -> BMI
chronotype -> alcohol
education -> "marital status"
education -> "metabolic profile"
education -> "night shift"
education -> "physical activity"
education -> BMI
education -> alcohol
education -> smoking
origin -> "marital status"
origin -> "metabolic profile"
origin -> "night shift"
origin -> "physical activity"
origin -> BMI
origin -> alcohol
origin -> education
origin -> smoking
sex -> "metabolic profile"
sex -> "night shift"
sex -> "physical activity"
sex -> BMI
sex -> alcohol
sex -> education
sex -> smoking
sleep -> "metabolic profile"
smoking -> "metabolic profile"
smoking -> "physical activity"
smoking -> BMI
}

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