Published February 24, 2026 | Version v1
Directed Acyclic Graph Open

Night-shift and Metabolomics

Contributors

  • Antonio d'Errico1 ORCID icon
  • 1 Utrecht University

Description

The developed DAG was used in the EPHOR-NIGHT project (European Project for Health and Occupational Research Night Shift Cohort) to study night-shift work association with workers' metabolomics.

Visualisation

Dagitty Code
dag {
bb="0,0,1,1"
"marital status" [adjusted,pos="0.200,0.335"]
"metabolic profile" [outcome,pos="0.818,0.839"]
"night shift" [exposure,pos="0.384,0.835"]
"physical activity" [pos="0.614,0.593"]
BMI [pos="0.611,0.478"]
age [adjusted,pos="0.057,0.095"]
alcohol [pos="0.560,0.143"]
center [adjusted,pos="0.057,0.498"]
chronotype [adjusted,pos="0.195,0.607"]
education [adjusted,pos="0.204,0.161"]
origin [adjusted,pos="0.056,0.207"]
sex [adjusted,pos="0.055,0.335"]
sleep [pos="0.610,0.739"]
smoking [pos="0.618,0.330"]
"marital status" -> "metabolic profile"
"marital status" -> "night shift"
"marital status" -> "physical activity"
"marital status" -> BMI
"marital status" -> alcohol
"marital status" -> smoking
"night shift" -> "metabolic profile"
"night shift" -> "physical activity"
"night shift" -> BMI
"night shift" -> alcohol
"night shift" -> sleep
"night shift" -> smoking
"physical activity" -> "metabolic profile"
BMI -> "metabolic profile"
BMI -> "physical activity"
age -> "marital status"
age -> "metabolic profile"
age -> "night shift"
age -> "physical activity"
age -> BMI
age -> alcohol
age -> chronotype
age -> education
age -> smoking
alcohol -> "metabolic profile"
alcohol -> BMI
alcohol -> sleep
alcohol -> smoking
center -> "marital status"
center -> "metabolic profile"
center -> "physical activity"
center -> BMI
center -> alcohol
center -> education
center -> origin
center -> smoking
chronotype -> "metabolic profile"
chronotype -> "night shift"
chronotype -> "physical activity"
chronotype -> BMI
chronotype -> alcohol
education -> "marital status"
education -> "metabolic profile"
education -> "night shift"
education -> "physical activity"
education -> BMI
education -> alcohol
education -> smoking
origin -> "marital status"
origin -> "metabolic profile"
origin -> "night shift"
origin -> "physical activity"
origin -> BMI
origin -> alcohol
origin -> education
origin -> smoking
sex -> "metabolic profile"
sex -> "night shift"
sex -> "physical activity"
sex -> BMI
sex -> alcohol
sex -> education
sex -> smoking
sleep -> "metabolic profile"
smoking -> "metabolic profile"
smoking -> "physical activity"
smoking -> BMI
}

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