Published February 24, 2026 | Version v1
Directed Acyclic Graph Open

Night-shift and Metabolomics

Contributors

  • 1 Utrecht University

Visualisation

Description

The developed DAG was used in the EPHOR-NIGHT project (European Project for Health and Occupational Research Night Shift Cohort) to study night-shift work association with workers' metabolomics.

Variables

14 nodes
  • night shift Exposure No description
  • metabolic profile Outcome No description
  • marital status No description
  • physical activity No description
  • BMI No description
  • age No description
  • alcohol No description
  • center No description
  • chronotype No description
  • education No description
  • origin No description
  • sex No description
  • sleep No description
  • smoking No description

Relationships

67 edges

List Matrix
  • marital status metabolic profile
  • marital status night shift
  • marital status physical activity
  • marital status BMI
  • marital status alcohol
  • marital status smoking
  • night shift metabolic profile
  • night shift physical activity
  • night shift BMI
  • night shift alcohol
  • night shift sleep
  • night shift smoking
  • physical activity metabolic profile
  • BMI metabolic profile
  • BMI physical activity
  • age marital status
  • age metabolic profile
  • age night shift
  • age physical activity
  • age BMI
  • age alcohol
  • age chronotype
  • age education
  • age smoking
  • alcohol metabolic profile
  • alcohol BMI
  • alcohol sleep
  • alcohol smoking
  • center marital status
  • center metabolic profile
  • center physical activity
  • center BMI
  • center alcohol
  • center education
  • center origin
  • center smoking
  • chronotype metabolic profile
  • chronotype night shift
  • chronotype physical activity
  • chronotype BMI
  • chronotype alcohol
  • education marital status
  • education metabolic profile
  • education night shift
  • education physical activity
  • education BMI
  • education alcohol
  • education smoking
  • origin marital status
  • origin metabolic profile
  • origin night shift
  • origin physical activity
  • origin BMI
  • origin alcohol
  • origin education
  • origin smoking
  • sex metabolic profile
  • sex night shift
  • sex physical activity
  • sex BMI
  • sex alcohol
  • sex education
  • sex smoking
  • sleep metabolic profile
  • smoking metabolic profile
  • smoking physical activity
  • smoking BMI

Read across: each marked cell is an edge from the row's variable to the column's.

  • No sign given
  • Directed
night shiftmetabolic profilemarital statusphysical activityBMIagealcoholcenterchronotypeeducationoriginsexsleepsmoking
night shift
metabolic profile
marital status
physical activity
BMI
age
alcohol
center
chronotype
education
origin
sex
sleep
smoking

Code

Submitted as opencausal_orer8blv.txt. Also available as:

JSON CSV DAGitty

This JSON follows CausalJSON 0.2, the Open Causal Graph Format.

{
  "$schema": "https://opencausal.org/causaljson/0.2/causaljson.schema.json",
  "graph": {
    "id": "orer8blv",
    "doi": "10.83031/orer8blv",
    "version": 1,
    "title": "Night-shift and Metabolomics",
    "description": "The developed DAG was used in the EPHOR-NIGHT project (European Project for Health and Occupational Research Night Shift Cohort) to study night-shift work association with workers' metabolomics.",
    "type": "dag",
    "created": "2026-02-24T13:39:23+00:00",
    "authors": [
      {
        "given_name": "Antonio",
        "family_name": "d'Errico",
        "orcid": "0000-0001-9805-600X",
        "affiliations": [
          {
            "name": "Utrecht University"
          }
        ]
      }
    ],
    "submitter": {
      "given_name": "Antonio",
      "family_name": "d'Errico",
      "orcid": "0000-0001-9805-600X"
    },
    "license": "CC-BY-4.0",
    "rights_url": "https://creativecommons.org/licenses/by/4.0/legalcode",
    "publisher": "Open Causal",
    "language": "en",
    "layout": {
      "coordinate_system": "screen"
    }
  },
  "nodes": [
    {
      "id": "marital_status",
      "label": "marital status",
      "position": {
        "x": 0.2,
        "y": 0.335
      }
    },
    {
      "id": "metabolic_profile",
      "label": "metabolic profile",
      "role": "outcome",
      "position": {
        "x": 0.818,
        "y": 0.839
      }
    },
    {
      "id": "night_shift",
      "label": "night shift",
      "role": "exposure",
      "position": {
        "x": 0.384,
        "y": 0.835
      }
    },
    {
      "id": "physical_activity",
      "label": "physical activity",
      "position": {
        "x": 0.614,
        "y": 0.593
      }
    },
    {
      "id": "BMI",
      "label": "BMI",
      "position": {
        "x": 0.611,
        "y": 0.478
      }
    },
    {
      "id": "age",
      "label": "age",
      "position": {
        "x": 0.057,
        "y": 0.095
      }
    },
    {
      "id": "alcohol",
      "label": "alcohol",
      "position": {
        "x": 0.56,
        "y": 0.143
      }
    },
    {
      "id": "center",
      "label": "center",
      "position": {
        "x": 0.057,
        "y": 0.498
      }
    },
    {
      "id": "chronotype",
      "label": "chronotype",
      "position": {
        "x": 0.195,
        "y": 0.607
      }
    },
    {
      "id": "education",
      "label": "education",
      "position": {
        "x": 0.204,
        "y": 0.161
      }
    },
    {
      "id": "origin",
      "label": "origin",
      "position": {
        "x": 0.056,
        "y": 0.207
      }
    },
    {
      "id": "sex",
      "label": "sex",
      "position": {
        "x": 0.055,
        "y": 0.335
      }
    },
    {
      "id": "sleep",
      "label": "sleep",
      "position": {
        "x": 0.61,
        "y": 0.739
      }
    },
    {
      "id": "smoking",
      "label": "smoking",
      "position": {
        "x": 0.618,
        "y": 0.33
      }
    }
  ],
  "edges": [
    {
      "source": "marital_status",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "marital_status",
      "target": "night_shift",
      "type": "directed"
    },
    {
      "source": "marital_status",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "marital_status",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "marital_status",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "marital_status",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "night_shift",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "night_shift",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "night_shift",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "night_shift",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "night_shift",
      "target": "sleep",
      "type": "directed"
    },
    {
      "source": "night_shift",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "physical_activity",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "BMI",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "BMI",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "marital_status",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "night_shift",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "chronotype",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "education",
      "type": "directed"
    },
    {
      "source": "age",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "alcohol",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "alcohol",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "alcohol",
      "target": "sleep",
      "type": "directed"
    },
    {
      "source": "alcohol",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "center",
      "target": "marital_status",
      "type": "directed"
    },
    {
      "source": "center",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "center",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "center",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "center",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "center",
      "target": "education",
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    },
    {
      "source": "center",
      "target": "origin",
      "type": "directed"
    },
    {
      "source": "center",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "chronotype",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "chronotype",
      "target": "night_shift",
      "type": "directed"
    },
    {
      "source": "chronotype",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "chronotype",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "chronotype",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "education",
      "target": "marital_status",
      "type": "directed"
    },
    {
      "source": "education",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "education",
      "target": "night_shift",
      "type": "directed"
    },
    {
      "source": "education",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "education",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "education",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "education",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "marital_status",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "night_shift",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "education",
      "type": "directed"
    },
    {
      "source": "origin",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "sex",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "sex",
      "target": "night_shift",
      "type": "directed"
    },
    {
      "source": "sex",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "sex",
      "target": "BMI",
      "type": "directed"
    },
    {
      "source": "sex",
      "target": "alcohol",
      "type": "directed"
    },
    {
      "source": "sex",
      "target": "education",
      "type": "directed"
    },
    {
      "source": "sex",
      "target": "smoking",
      "type": "directed"
    },
    {
      "source": "sleep",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "smoking",
      "target": "metabolic_profile",
      "type": "directed"
    },
    {
      "source": "smoking",
      "target": "physical_activity",
      "type": "directed"
    },
    {
      "source": "smoking",
      "target": "BMI",
      "type": "directed"
    }
  ]
}
source,target,edge_type
marital_status,metabolic_profile,directed
marital_status,night_shift,directed
marital_status,physical_activity,directed
marital_status,BMI,directed
marital_status,alcohol,directed
marital_status,smoking,directed
night_shift,metabolic_profile,directed
night_shift,physical_activity,directed
night_shift,BMI,directed
night_shift,alcohol,directed
night_shift,sleep,directed
night_shift,smoking,directed
physical_activity,metabolic_profile,directed
BMI,metabolic_profile,directed
BMI,physical_activity,directed
age,marital_status,directed
age,metabolic_profile,directed
age,night_shift,directed
age,physical_activity,directed
age,BMI,directed
age,alcohol,directed
age,chronotype,directed
age,education,directed
age,smoking,directed
alcohol,metabolic_profile,directed
alcohol,BMI,directed
alcohol,sleep,directed
alcohol,smoking,directed
center,marital_status,directed
center,metabolic_profile,directed
center,physical_activity,directed
center,BMI,directed
center,alcohol,directed
center,education,directed
center,origin,directed
center,smoking,directed
chronotype,metabolic_profile,directed
chronotype,night_shift,directed
chronotype,physical_activity,directed
chronotype,BMI,directed
chronotype,alcohol,directed
education,marital_status,directed
education,metabolic_profile,directed
education,night_shift,directed
education,physical_activity,directed
education,BMI,directed
education,alcohol,directed
education,smoking,directed
origin,marital_status,directed
origin,metabolic_profile,directed
origin,night_shift,directed
origin,physical_activity,directed
origin,BMI,directed
origin,alcohol,directed
origin,education,directed
origin,smoking,directed
sex,metabolic_profile,directed
sex,night_shift,directed
sex,physical_activity,directed
sex,BMI,directed
sex,alcohol,directed
sex,education,directed
sex,smoking,directed
sleep,metabolic_profile,directed
smoking,metabolic_profile,directed
smoking,physical_activity,directed
smoking,BMI,directed

dag {
marital_status [label="marital status",pos="0.2,0.335"]
metabolic_profile [outcome,label="metabolic profile",pos="0.818,0.839"]
night_shift [exposure,label="night shift",pos="0.384,0.835"]
physical_activity [label="physical activity",pos="0.614,0.593"]
BMI [pos="0.611,0.478"]
age [pos="0.057,0.095"]
alcohol [pos="0.56,0.143"]
center [pos="0.057,0.498"]
chronotype [pos="0.195,0.607"]
education [pos="0.204,0.161"]
origin [pos="0.056,0.207"]
sex [pos="0.055,0.335"]
sleep [pos="0.61,0.739"]
smoking [pos="0.618,0.33"]
marital_status -> metabolic_profile
marital_status -> night_shift
marital_status -> physical_activity
marital_status -> BMI
marital_status -> alcohol
marital_status -> smoking
night_shift -> metabolic_profile
night_shift -> physical_activity
night_shift -> BMI
night_shift -> alcohol
night_shift -> sleep
night_shift -> smoking
physical_activity -> metabolic_profile
BMI -> metabolic_profile
BMI -> physical_activity
age -> marital_status
age -> metabolic_profile
age -> night_shift
age -> physical_activity
age -> BMI
age -> alcohol
age -> chronotype
age -> education
age -> smoking
alcohol -> metabolic_profile
alcohol -> BMI
alcohol -> sleep
alcohol -> smoking
center -> marital_status
center -> metabolic_profile
center -> physical_activity
center -> BMI
center -> alcohol
center -> education
center -> origin
center -> smoking
chronotype -> metabolic_profile
chronotype -> night_shift
chronotype -> physical_activity
chronotype -> BMI
chronotype -> alcohol
education -> marital_status
education -> metabolic_profile
education -> night_shift
education -> physical_activity
education -> BMI
education -> alcohol
education -> smoking
origin -> marital_status
origin -> metabolic_profile
origin -> night_shift
origin -> physical_activity
origin -> BMI
origin -> alcohol
origin -> education
origin -> smoking
sex -> metabolic_profile
sex -> night_shift
sex -> physical_activity
sex -> BMI
sex -> alcohol
sex -> education
sex -> smoking
sleep -> metabolic_profile
smoking -> metabolic_profile
smoking -> physical_activity
smoking -> BMI
}

Discussion

admin
09.10.2026 10:47

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