Javier Mancilla Galindo

This directed acyclic graph is used to inform the estimation of the causal effect of lifetime cumulative exposure to asbestos (main exposure) on lung cancer (outcome) in the context of individual participant data (IPD) meta-analysis of the SYNERGY pooled case-control study [1]. Co-exposure to other occupational lung carcinogens is represented with respiratory cristaline silica (RCS) as a motivating example. True exposure is unobserved (X_asb_true and X_rcs_true) and thus estimated with the job exposure matrix SYN-JEM (asbestos_cum0 and silica_cum0), resulting in loss of individual variation (Epsilon), and exposure error terms (U) that are independent of outcome status (Berkson-type error) [2]. The …